Xeris Pharmaceuticals Begins Dosing Patients in a Phase 2 Clinical Trial Evaluating Its Novel Fixed-Ratio Co-Formulation of Pramlintide-Insulin for Diabetes
Currently, pramlintide and insulin must be administered as two injections at separate sites before every meal, complicating the maintenance process for patients. The Company’s XeriSol™ technology allows for simultaneous concentration and stabilization of insulin and pramlintide, which are incompatible in aqueous (water-based) formulations. Xeris is leveraging its unique capability to develop a new fixed-ratio, co-formulation of pramlintide and insulin in a single injection to potentially improve glycemic control after meals in people with diabetes. In addition to the effects of insulin, pramlintide enhances glucose control by slowing the absorption of carbohydrates in the body and serves to complement the body’s interaction with insulin to regulate blood sugar levels.
“The premise of our technology is to simplify and improve therapies that patients rely on every day. With this liquid co-formulation, we have the opportunity to fully unlock the potential of pramlintide in helping persons with diabetes manage their blood sugar levels with a simple combination of commonly used therapies,” said
The randomized, open-label, cross-over study will assess the investigational treatment in a group of 18 adults with Type 1 diabetes. The primary objective of the study is to evaluate the pharmacodynamic (PD) and pharmacokinetic (PK) properties of a single injection of pramlintide-insulin compared to single doses of regular insulin and regular insulin plus pramlintide (co-administered as separate injections).
The Company anticipates reporting data from this study in the first half of 2020. For more information on Xeris’ pramlintide-insulin study, visit clinicaltrials.gov, identifier NCT04074317.
About
Xeris (Nasdaq: XERS) is a specialty pharmaceutical company delivering innovative solutions to simplify the experience of administering important therapies that people rely on every day around the world.
With a novel technology platform that enables ready-to-use, room-temperature stable formulations of injectable and infusible therapies, the company is advancing a portfolio of solutions in various therapeutic categories, including its first commercial product, Gvoke™. Its proprietary XeriSol™ and XeriJect™ formulation technologies have the potential to offer distinct advantages over conventional product formulations, including eliminating the need for reconstitution, enabling long-term, room-temperature stability, significantly reducing injection volume, and eliminating the requirement for intravenous (IV) infusion. With Xeris’ technology, new product formulations are designed to be easier to use by patients, caregivers, and health practitioners and help reduce costs for payers and the healthcare system.
Xeris is headquartered in
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Investor Contact
Allison Wey
Senior Vice President, Investor Relations and Corporate Communications
awey@xerispharma.com
312-736-1237